Andrew Holding

Andrew is a Senior Research Associate and Fellow of Downing College Cambridge. Within the lab he is responsible for the experimental research programme, his research is working to obtain evidence on the dynamic nature of nuclear receptors, include the oestrogen receptor in breast cancer tumour cells. This will provide the basis for the development of a quantitative model and facilitate our understanding of what drives this process. In the long term, the model could be used to predict the effects of perturbing components of the pathway with drugs and potentially lead to improved combinatorial treatment regimes.

Degrees

PhD in Chemical Biology
Studies on the biosynthesis of non-ribosomal peptides
University of Cambridge, UK

Masters in Chemistry
University of Oxford, UK

Vita

2015 - date
Fellow of Natural Sciences
Downing College

2015 - date
Senior Research Associate
Cancer Research UK Cambridge Research Institute

2013 - 2014
Research Associate
Cancer Research UK Cambridge Research Institute

2009 - 2013
Career Development Fellow
MRC Laboratory of Molecular Biology

2005 - 2009
PhD student
Deparment of Chemistry, University of Cambridge, UK.
Advisors: Dr. J. Spencer and Dr. F. Leeper

 
 
 

Awards and fellowships

2018 Turing Fellowsing, Alan Turing Institute

2017 Thomas Jefferson Visiting Fellow at University of Virginia

2017 CRUK Research Travel Award

2015 CRUK Rising Star in Research Engagement Prize

2015 Fellow Downing College

2014 Unltd Try-It Award

2013 College Lecturer and Bye-Fellow Downing College

2012 Wellcome Trust People Award

2012 British Mass Spectrometry Society Travel Award

2012 MRC Award via the Special Awards Scheme for contributions to the MRC

2012 British Science Association Media Fellowship

2011 UnLtd Catalyst Award for Social Entrepreneurship

2009 MRC Career Development Fellowship

2005 BBSRC PhD Studentship

Professional Memberships

2015 Fellow of the Higher Education Academy

2014 Member Biochemical Society

2009 Member Royal Society of Chemistry

Andrew Holding

Andrew Holding
University of Cambridge
CRUK Cambridge Institute
Li Ka Shing Centre
Robinson Way
Cambridge, CB2 0RE, UK
e: first.last@cruk.cam.ac.uk
p: +44 (0) 1223 769 696
w: Andrew Holding

BCC logo Cambridge University

Research

Publications

Oral Presentations

  1. Integrative analysis of ER-α in breast cancer reveals a robust and sustained response to estra-2-diol
    Keynote speaker, Biosciences Symposium, 2018, Essex.
  2. Network Dynamics of ER-α activation reveals reprogramming of GRHL2
    Applied Bioinformatics In Life Sciences, 2018, Leuven, Belgium.
  3. Utilising mass spectrometry for the structural and functional analysis of complex systems in medical research
    Invited speaker, 2016, University of Essex, Colchester, UK.
  4. Visualizing gene regulation: a combined proteomic and genomic approach for the structural analysis of steroid hormone receptor complexes
    Invited speaker, 4th International Congress on Analytical Proteomics, 2015, Lisbon, Portugal.
  5. Bringing Proteogenomics to the study of ER+ breast cancer
    Invited speaker, 2014, MRC Cancer Unit, Cambridge, UK.
  6. Interactions within the E. coli Replisome
    Mini-symposium on Biophysics, 2012, MRC Laboratory of Molecular Biology.
  7. Interactions within the E. coli Replisome
    Proteomics Methods Forum, 2012, Barts Cancer Institue, London, UK.
  8. Cross-linking in mass spectrometry
    Proteomics Methods Forum, 2010, Department of Biochemistry, University of Cambridge.
  9. Cross-linking in mass spectrometry
    Mini-symposium on Biophysics, 2010, MRC Laboratory of Molecular Biology.

Poster Presentations

  1. Parallel Factor ChIP Provides Essential Internal Control for Quantitative Differential ChIP-seq
    M. J. Guertin, A. E. Cullen, F. Markowetz A. N. Holding,
    Cambridge Cancer Centre Symposium, 2017, Cambridge, UK.
  2. ChIP-MS/TMT: a quantative proteomic analysis of steroid hormone receptor activation.
    A. N. Holding, F. Markowetz
    64th ASMS Conference on Mass Spectrometry and Allied Topics, 2016, San Antonio, Texas, USA
  3. Visualising gene regulation: A combined proteomic and genomic approach for the analysis of steroid hormone receptor complexes.
    A. N. Holding, J. C. Carroll, F. Markowetz
    29th Annual Symposium of the Protein Society, Barcelona, Spain
  4. Visualising gene regulation: A combined proteomic and genomic approach for the analysis of steroid hormone receptor complexes.
    A. N. Holding, J. C. Carroll, F. Markowetz
    Cambridge Cancer Centre Symposium, 2015, Cambridge, UK.
  5. Hekate – Software suite for the mass spectrometric analysis & three-dimensional visualization of cross-linked protein samples.
    A. N. Holding, Y. Liu, H. K. Salter, M. L. Lamers, S. L. Bullock, M. J. Skehel
    Postdoctoral Career Development Day, Cancer Research UK, 2014,London, UK
  6. A shared binding site for different cargo adaptors in the asymmetric coiled-coil structure of the dynein co-factor Bicaudal-D
    H. K. Salter, Y. Liu, A. N. Holding, C. Johnson, E. Stephens, J. Walshaw, S. L. Bullock
    The American Society For Cell Biology Annual Meeting, 2012, San Franciso, CA, USA.
  7. Resolving interactions involved in binding of the dynein co-factor Bicaudal-D (BicD) to Rab6
    Andrew N Holding, Elaine Stephens, Mark Skehel.
    EuPA/BSPR Prteomic Meeting, 2012, Glasgow, Scotland.
  8. Resolving interactions involved in binding of the dynein co-factor Bicaudal-D (BicD) to Rab6
    Andrew N Holding, Elaine Stephens.
    60th ASMS Conference on Mass Spectrometry and Allied Topics, 2012, Vancouver Convention Centre, Vancouver, BC, Canada.
  9. XL-SAXS and DNA replication
    Ana Toste Rêgo, Andrew Holding, Michal Hammel, Elaine Stephens, John Kuriyan and Meindert H. Lamers.
    Current Opinion in Structural Biology & DNA Repair, 2011, Amsterdam, The Netherlands
  10. Development of arginine and guanine specific isotopically-labelled linkers for the characterisation of binding interactions by mass spectrometry
    Andrew N Holding, Elaine Stephens.
    59th ASMS Conference on Mass Spectrometry and Allied Topics, 2011, Colorado Convention Center, Denver, CO, USA.
  11. Sdo1/Efl1 interaction site mapped by photocrosslinking
    Andrew N Holding, Nicholas Basse, Alan Warren, Elaine Stephens.
    Memorial symposium for Dr. Jonathan Spencer, 2010, University of Cambridge.
  12. Investigation into the mechanism of phenolic couplings during the biosynthesis of glycopeptide antibiotics
    Andrew N Holding, Jonathan B Spencer.
    Zing Conference in Natural Products, 2009, Antigua.