Systems Genetics - linking genotypes and phenotypes
Florian Markowetz and Michael Boutros (eds.)
Cambridge University Press
Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes.
This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes.
"Since the completion of the Human Genome Project we hold the "book of life" in our hands, but for the most part, we do not understand how to interpret it. We lack an understanding of the grammar that it is written in. With this book the authors put together an impressive collection of chapters that provide insights into our current efforts to understand how genetic information is integrated, coordinated and ultimately assembled into biological systems. If you are interested in how to decipher the grammar of life this is a must read!" says Frank Buchholz, TU Dresden, Germany
Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomices cerevisiae, Drosophila melanogaster, as well as from human studies.
Researchers and graduate students in genetics, functional genomics, bioinformatics, computational biology, systems biology, and biotechnology will find this title a valuable and timely resource.
Table of contents
- An introduction to Systems Genetics
F Markowetz and M Boutros
- Computational paradigms for analyzing genetic interaction networks
Pons et al
- Mapping genetic interactions across many phenotypes in metazoan cells
Laufer et al
- Genetic interactions and network reliability
E Delgado-Eckert and N Beerenwinkel
- Synthetic lethality and chemoresistance in cancer
K Maxeld and A Whitehurst
- Joining the dots - network analysis of gene perturbation data
Xin Wang, Ke Yuan, Florian Markowetz
- High Content Screening in Infectious Diseases: new drugs against bugs
AP Mäurer, PR Braun, K Holden-Dye, TF Meyer
- Inferring genetic architecture from systems genetics studies
X Sun, S Mohr, A Vinayagam, P Hong N Perrimon
- Bayesian inference for model selection: An application to aberrant signalling pathways in chronic myeloid leukaemia
L Hopcroft, B Calderhead, P Gallipoli, T Holyoake and M Girolami
- Dynamic network models of protein complexes
Y Park and JS Bader
- Phenotype state spaces and strategies for exploring them
Andreas Hadjiprocopis and Rune Linding
- Automated behavioural fingerprinting of C. elegans mutants
Andre E.X. Brown and William R. Schafer