Inferring genetic architecture from perturbation maps

Design and Analysis of Single and Combinatorial Gene Perturbation Screens

Modern high-throughput screening approaches are key technologies at the forefront of genetic research. They make it possible to describe a biological response to thousands of experimental perturbations.

This workshop will focus on novel experimental and computational strategies to use perturbation screens for dissecting cellular regulatory networks and disease mechanisms. The participants are leading international scientists covering both theoretical and experimental approaches for phenotyping and a wide range of research areas, model organisms and experimental techniques.

Together we will define the main unanswered questions in the field and identify the next key challenges: Which (computational or experimental) developments will drive the field forward in the next years?


Each participant gives a talk of 15 min, followed by 5 min of questions. At the end of the talk, each participant answers the question: "What is the next big thing in my field?" At the end of each session two participants kick-start the general discussion by summarizing the main results of the talks.

The workshop starts on Thursday with lunch (12oo-13:30) and ends Saturday night, with general departure on Sunday morning. There will be an afternoon session on Sept 15 and two sessions on both Sept 16 and Sept 17.

Please download the preliminary programme.


Ahringer, Julie University of Cambridge UK Exp
Beerenwinkel, Niko ETH Zurich CH Comp
Beijersbergen, Roderick NKI Amsterdam NL Exp
Blomberg, Anders University of Gothenburg SE Exp
Boutros, Michael DKFZ Heidelberg DE Exp
Di Bernardo, Diego Telethon Institute, Naples IT Comp
Gentleman, Robert Genentech US Comp
Hatzigeorgiou, Artemis BSRC Alexander Fleming GR Comp
Holstege, Frank Utrecht University NL Exp
Huber, Wolfgang EMBL Heidelberg DE Comp
Ketteler, Robin UCL LMCB UK Exp
Lehner, Ben EMBL-CRG Barcelona ES Exp
Margalit, Hanah The Hebrew University IL Comp
Markowetz, Florian CRUK Cambridge Research Institute UK Comp
Mäurer, Andre MPI-IB Berlin DE Exp
Michoel, Tom Freiburg Institute for Advanced Studies DE Comp
Moreau, Yves KU Leuven BE Comp
Mulder, Klaas CRUK Cambridge Research Institute UK Exp
Myers, Chad University of Minnesota US Comp
Nelander, Sven University of Gothenburg SE Comp/Exp
Nijman, Sebastian Research Center for Molecular Medicine AT Exp
Pelkmans, Lucas ETH Zurich CH Exp
Saez-Rodriguez, Julio EMBL-EBI UK Comp
Spang, Rainer University of Regensburg DE Comp
Taipale, Jussi Helsinki University FI Exp
Tavernier, Jan Ghent University BE Exp
Tresch, Achim LMU Munich DE Comp
Vert, Jean-Philippe Ecole de Mines, Paris FR Comp
Wessels, Lodwyk NKI NL Comp
Wilson, Paul GlaxoSmithKline UK Comp
Zupan, Blaz University of Ljubljana SI Comp



The workshop will be held at Lucy Cavendish College, Lady Margaret Road, Cambridge, CB3 0BU, UK. Telephone: + 44 (0)1223 332 181

The closest airport is London Stansted, from where Cambridge can easily be reached by train (30min) or bus (50min). From the train or bus station it is quick cab ride to Lucy Cavendish College. Further directions can be found here or in this map:

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To get reimbursed for parts of your travel costs (up to a maximum amount), please fill out the payment form (or as .doc with comments) and the bank details form and send both until 1st Oct 2011 to Tania Smith (Cancer Research UK Cambridge Research Institute, Robinson Way, Cambridge CB2 0RE, UK. Email: tania.smith||


The workshop is featured in the Dec 2011 FFG newsletter

Date and venue

Sept 15 - 17, 2011
Lucy Cavendish College
Cambridge, UK
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The organizers have reserved single rooms for invited speakers at Lucy Cavendish College, Cambridge, for three nights (Thu-Sat). More rooms are available for other participants.


Participants organize their travel to Cambridge. We recommend to come in on Thursday morning and travel back on Sunday morning.
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Florian Markowetz
p: +44 (0) 1223 40 4315
Michael Boutros
p: +49 (0) 6221 42 1951


Tania Smith


This workshop is mainly funded by the European Science Foundation in their Frontiers of Functional Genomics program.

The European Science Foundation (ESF) provides a platform for its Member Organisations to advance science and explore new directions for research at the European level.

Established in 1974 as an independent non-governmental organisation, the ESF currently serves 78 Member Organisations across 30 countries.