Inferring genetic architecture from perturbation maps

Design and Analysis of Single and Combinatorial Gene Perturbation Screens

Modern high-throughput screening approaches are key technologies at the forefront of genetic research. They make it possible to describe a biological response to thousands of experimental perturbations.

This workshop will focus on novel experimental and computational strategies to use perturbation screens for dissecting cellular regulatory networks and disease mechanisms. The participants are leading European scientists covering both theoretical and experimental approaches for phenotyping and a wide range of research areas, model organisms and experimental techniques.

Together we will define the main unanswered questions in the field and identify the next key challenges: Which (computational or experimental) developments will drive the field forward in the next years?

The workshop will center around five key areas:

  1. Designing phenotypes: What are the challenges to utilize quantitative phenotypes?
  2. From phenotypes to mechanisms: what do perturbation effects tell us about protein function and cellular networks?
  3. Gene-gene and gene-drug interactions: How do epistatic effects relate to cellular networks and pathways?
  4. Modeling the cell: how can we predict phenotypes and synthetic interactions?
  5. Integrative design and analysis: what other complementary data types and experiments can maximize the information gained from perturbations?


Each participant gives a talk of 18 min, followed by 5 min of questions. At the end of the talk, each participant answers the question: "What is the next big thing in my field?"

At the end of each session two participants kick-start the general discussion by summarizing the main results of the talks they have heard.

Please download the preliminary programme.



Participation in this exploratory workshop was by invitation only.

Ahringer, Julie University of Cambridge UK Exp
Arrieumerlou, Cecile Biozentrum Basel CH Exp
Baum, Buzz LMCB UCL UK Exp
Beerenwinkel, Niko ETH Zurich CH Comp
Beijersbergen, Roderick NKI Amsterdam NL Exp
Bjoerkegren, Johan Karolsinka Insitute Stockholm SE Exp
Boutros, Michael DKFZ Heidelberg DE Exp
Cetin-Atalay, Rengul Bilkent University TR Exp/Comp
Di Bernardo, Diego Telethon Institute, Naples IT Comp
Downward, Julian CR-UK London Research Institute UK Exp
Fisher, Jasmin Microsoft Research Cambridge UK Comp
Gambin, Anna University of Warsaw PL Comp
Hatzigeorgiou, Artemis BSRC Alexander Fleming GR Comp
Huber, Wolfgang EMBL Heidelberg DE Comp
Markowetz, Florian CR-UK Cambridge Research Institute UK Comp
Meyer, Thomas MPI for Infection Biology, Berlin DE Exp
Michoel, Tom Freiburg Institute for Advanced Studies DE Comp
Moreau, Yves KU Leuven BE Comp
Myers, Chad University of Minnesota US Comp
Nijman, Sebastian Research Center for Molecular Medicine AT Exp
Papp, Balazs Hung Acad of Sciences, Szeged HU Comp
Pelkmans, Lucas ETH Zurich CH Exp
Saez-Rodriguez, Julio EMBL-EBI UK Comp
Spang, Rainer University of Regensburg DE Comp
Taipale, Jussi Helsinki University FI Exp
Tavernier, Jan Ghent University BE Exp
Vert, Jean-Philippe Ecole de Mines, Paris FR Comp
Zupan, Blaz University of Ljubljana SI Comp



The workshop will be held at Lucy Cavendish College, Lady Margaret Road, Cambridge, CB3 0BU, UK. Telephone: + 44 (0)1223 332 181

The closest airport is London Stansted, from where Cambridge can easily be reached by train (30min) or bus (50min). From the train or bus station it is quick cab ride to Lucy Cavendish College. Further directions can be found here or in this map:

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To get reimbursed for your travel costs (up to a maximum amount), please fill out the payment form (or as .doc with comments) and the bank details form and send both to Tania Smith
Cancer Research UK Cambridge Research Institute
Robinson Way
Cambridge CB2 0RE, UK.
email: tania.smith||


Date and venue

Sept 9 - 11, 2010
Lucy Cavendish College
Cambridge, UK
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The organizers have reserved single rooms for all participants at Lucy Cavendish College.


Participants organize their own travel to Cambridge.
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Florian Markowetz
p: +44 (0) 1223 40 4315
Michael Boutros
p: +49 (0) 6221 42 1951


This workshop is mainly funded by the European Science Foundation in their exploratory workshops series. [EW09-006 - LESC]