Inferring genetic architecture from perturbation maps
Design and Analysis of Single and Combinatorial Gene Perturbation Screens
Modern high-throughput screening approaches are key technologies at the forefront of genetic research. They make it possible to describe a biological response to thousands of experimental perturbations.
This workshop will focus on novel experimental and computational strategies to use perturbation screens for dissecting cellular regulatory networks and disease mechanisms. The participants are leading European scientists covering both theoretical and experimental approaches for phenotyping and a wide range of research areas, model organisms and experimental techniques.
Together we will define the main unanswered questions in the field and identify the next key challenges: Which (computational or experimental) developments will drive the field forward in the next years?
The workshop will center around five key areas:
- Designing phenotypes: What are the challenges to utilize quantitative phenotypes?
- From phenotypes to mechanisms: what do perturbation effects tell us about protein function and cellular networks?
- Gene-gene and gene-drug interactions: How do epistatic effects relate to cellular networks and pathways?
- Modeling the cell: how can we predict phenotypes and synthetic interactions?
- Integrative design and analysis: what other complementary data types and experiments can maximize the information gained from perturbations?
Each participant gives a talk of 18 min, followed by 5 min of questions. At the end of the talk, each participant answers the question: "What is the next big thing in my field?"
At the end of each session two participants kick-start the general discussion by summarizing the main results of the talks they have heard.
Please download the preliminary programme.
Participation in this exploratory workshop was by invitation only.
|Ahringer, Julie||University of Cambridge||UK||Exp|
|Arrieumerlou, Cecile||Biozentrum Basel||CH||Exp|
|Baum, Buzz||LMCB UCL||UK||Exp|
|Beerenwinkel, Niko||ETH Zurich||CH||Comp|
|Beijersbergen, Roderick||NKI Amsterdam||NL||Exp|
|Bjoerkegren, Johan||Karolsinka Insitute Stockholm||SE||Exp|
|Boutros, Michael||DKFZ Heidelberg||DE||Exp|
|Cetin-Atalay, Rengul||Bilkent University||TR||Exp/Comp|
|Di Bernardo, Diego||Telethon Institute, Naples||IT||Comp|
|Downward, Julian||CR-UK London Research Institute||UK||Exp|
|Fisher, Jasmin||Microsoft Research Cambridge||UK||Comp|
|Gambin, Anna||University of Warsaw||PL||Comp|
|Hatzigeorgiou, Artemis||BSRC Alexander Fleming||GR||Comp|
|Huber, Wolfgang||EMBL Heidelberg||DE||Comp|
|Markowetz, Florian||CR-UK Cambridge Research Institute||UK||Comp|
|Meyer, Thomas||MPI for Infection Biology, Berlin||DE||Exp|
|Michoel, Tom||Freiburg Institute for Advanced Studies||DE||Comp|
|Moreau, Yves||KU Leuven||BE||Comp|
|Myers, Chad||University of Minnesota||US||Comp|
|Nijman, Sebastian||Research Center for Molecular Medicine||AT||Exp|
|Papp, Balazs||Hung Acad of Sciences, Szeged||HU||Comp|
|Pelkmans, Lucas||ETH Zurich||CH||Exp|
|Spang, Rainer||University of Regensburg||DE||Comp|
|Taipale, Jussi||Helsinki University||FI||Exp|
|Tavernier, Jan||Ghent University||BE||Exp|
|Vert, Jean-Philippe||Ecole de Mines, Paris||FR||Comp|
|Zupan, Blaz||University of Ljubljana||SI||Comp|
The workshop will be held at Lucy Cavendish College, Lady Margaret Road, Cambridge, CB3 0BU, UK. Telephone: + 44 (0)1223 332 181
The closest airport is London Stansted, from where Cambridge can easily be reached by train (30min) or bus (50min). From the train or bus station it is quick cab ride to Lucy Cavendish College. Further directions can be found here or in this map:
To get reimbursed for your travel costs (up to a maximum amount), please fill out the payment form (or as .doc with comments) and the bank details form and send both to Tania Smith
Cancer Research UK Cambridge Research Institute
Cambridge CB2 0RE, UK.