Inferring genetic architecture from perturbation maps
Design and Analysis of Single and Combinatorial Gene Perturbation Screens
Modern high-throughput screening approaches are key technologies at the forefront of genetic research. They make it possible to describe a biological response to thousands of experimental perturbations.
This workshop will focus on novel experimental and computational strategies to use perturbation screens for dissecting cellular regulatory networks and disease mechanisms. The participants are leading European scientists covering both theoretical and experimental approaches for phenotyping and a wide range of research areas, model organisms and experimental techniques.
The workshop will center around five key areas:
- Designing phenotypes: What are the challenges to utilize quantitative phenotypes?
- From phenotypes to mechanisms: what do perturbation effects tell us about protein function and cellular networks?
- Genetic interactions: How do epistatic effects relate to cellular networks and pathways?
- Genes and drugs: what do chemical genomics screens teach us about disease mechanisms?
- Modeling the cell: how can we predict phenotypes and synthetic interactions?
Directions
Sept 9 - 11, 2010 at Lucy Cavendish College, Cambridge, UK. Directions can be found here or in this map:
