Design and Analysis of Single and Combinatorial Gene Perturbation Screens

Modern high-throughput screening approaches are key technologies at the forefront of genetic research. They make it possible to describe a biological response to thousands of experimental perturbations.

This workshop will focus on novel experimental and computational strategies to use perturbation screens for dissecting cellular regulatory networks and disease mechanisms. The participants are leading international scientists covering both theoretical and experimental approaches for phenotyping and a wide range of research areas, model organisms and experimental techniques.

Together we will define the main unanswered questions in the field and identify the next key challenges: Which (computational or experimental) developments will drive the field forward in the next years?


Preliminary programme [PDF]

The workshop starts on Thursday with lunch (12oo-13:30) and ends Saturday night, with general departure on Sunday morning. There will be an afternoon session on Aug 30 and two sessions on both Aug 31 and Sept 01.



Participation in this workshop is by invitation only. Confirmed participants include:

Altschuler, Steven University of Texas, Dallas US Comp/Exp
Andrews, Brenda Univ of Toronto CA Exp
Babu, Madan MRC-LMB Cambridge UK Comp
Beerenwinkel, Niko ETH Zurich CH Comp
Beijersbergen, Roderick NKI Amsterdam NL Exp
Beyer, Andreas BioTec, TU Dresden DE Comp
Blüthgen, Nils Charite / HU Berlin DE Comp
Boutros, Michael DKFZ Heidelberg DE Exp
Boone, Charlie Univ of Toronto CA Exp
Buchholz, Frank MPI-CBG, Dresden DE Exp
Fröhlich, Holger Bonn DE Comp
Gentleman, Robert Genentech US Comp
Gunsalus, Kris NYU US Comp/Exp
Horn, David LSHTM, London UK Exp
Huber, Wolfgang EMBL Heidelberg DE Comp
Lehner, Ben EMBL-CRG Barcelona ES Exp
Lord, Chris ICR, London UK Exp
Margalit, Hanah The Hebrew University IL Comp
Markowetz, Florian CRUK Cambridge Research Institute UK Comp
Mäurer, Andre MPI-IB, Berlin DE Exp
Meyer, Thomas MPI-IB, Berlin DE Exp
Michoel, Tom The Roslin Institute, Edinburgh UK Comp
Moreau, Yves KU Leuven BE Comp
Mulder, Klaas NCMLS Nijmegen NL Exp
Nelander, Sven University of Gothenburg SE Comp/Exp
Nijman, Sebastian Research Center for Mol. Medicine AT Exp
Saez-Rodriguez, Julio EMBL-EBI UK Comp
Schwarz, Roland EMBL/EBI UK Comp
Schwikowski, Benno Pasteur Institute, Paris FR Comp
Sers, Christine Charite Berlin DE Exp
Shamir, Ron Tel Aviv University IL Comp
Taipale, Jussi Helsinki University FI Exp
Tavernier, Jan Ghent University BE Exp
Teichmann, Sarah MRC/LMB UK Comp
Tresch, Achim MPI-PZ and Unviversity of Cologne DE Comp
Vert, Jean-Philippe Ecole de Mines, Paris FR Comp
Wang, Xin CRUK CRI UK Comp
Wessels, Lodwyk NKI NL Comp
Wilson, Paul GlaxoSmithKline UK Comp
Yeger-Lotem, Esti Ben-Gurion University IL Comp



The workshop will be held at Lucy Cavendish College, Lady Margaret Road, Cambridge, CB3 0BU, UK. Telephone: + 44 (0)1223 332 181

The closest airport is London Stansted, from where Cambridge can easily be reached by train (30min) or bus (50min). From the train or bus station it is quick cab ride to Lucy Cavendish College. Further directions can be found here or in this map:

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To get reimbursed for parts of your travel costs (up to a maximum amount), please fill out the expenses claim form and send it until 28th Sept 2012 to Tania Smith (Email: tania.smith|| Cancer Research UK Cambridge Research Institute, Robinson Way, Cambridge CB2 0RE, UK.)


Date and venue

Aug 30 - Sept 01, 2012
Lucy Cavendish College
Cambridge, UK
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The organizers have reserved single rooms at Lucy Cavendish College, Cambridge, for three nights (Thu-Sat).


Participants organize their travel to Cambridge. Parts of the travel costs will be reimbursed up to a fixed maximum amount. We recommend to come in on Thursday morning and travel back on Sunday morning.
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Florian Markowetz
p: +44 (0) 1223 40 4315
Michael Boutros
p: +49 (0) 6221 42 1951


Tania Smith