The Markowetz lab at Cancer Research UK's Cambridge Research Institute develops algorithms and statistics to leverage complex and heterogeneous data sources for biomedical research.

Our research is grounded in close collaborations with experimental partners. Together we approach pivotal questions in biology and medicine by computationally guided experimentation: biological and clinical questions motivate the development of novel statistical algorithms, which then guide the next round of experiments.

Research

Computational diagnostics > With our partners at CRI we develop systems approaches to dissect the genomic basis of cancer. We aim to identify disrupted signaling pathways in tumors, to discover novel biomarkers, and to diagnose disease sub-types by their molecular signatures.

Stem cell genomics > With international collaboration partners we work on defining regulatory networks of key pluripotency modulators, comparing them between different stem cell types, and characterizing their re-wiring during differentation.

Understanding the cell by breaking it > One of our key areas of interest is developing strategies to reconstruct cellular pathways and their condition-specific re-wiring from gene perturbation assays.

Software

  • nem - an R/Bioconductor package to infer Nested Effects Models for phenotypic hierarchies

... more software

Events

... more events

Selected publications

  • How to understand the cell by breaking it: network analysis of gene perturbation screens
    F. Markowetz, PLoS Comp Bio 2010 6(2). [ PMID:20195495 ]
  • Systems-level dynamic analyses of fate change in murine embryonic stem cells. R. Lu, F. Markowetz, et al. Nature 2009; 462(7271):358-362
    [ PMID:19924215 ]
  • Structure Learning in Nested Effects Models. A. Tresch, F. Markowetz. Statistical Applications in Genetics and Molecular Biology: Vol. 7: Iss. 1, Article 9, 2008. [ PMID:18312214 ]

... more publications

CRI PI Post Docs Students

Contact
CR UK - CRI
Li Ka Shing Centre
Robinson Way
Cambridge, CB2 0RE, UK
e: first.last@cancer.org.uk
p: +44 (0) 1223 40 4315
f: +44 (0) 1223 40 4199

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